Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.
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چکیده
منابع مشابه
Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.
Continuous exposure of cells to hormonal agonists often causes a rapid waning of the stimulated response. This desensitization effect has been extensively studied in the beta-adrenergic receptor system, and attributed largely to the rapid phosphorylation of the receptor by two kinases. Over a similar time frame (seconds to minutes), agonists also trigger a selective loss in the capacity of rece...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1993
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)54155-7